Juniper Publishers-Open Access Journal of Toxicology

 Open Access Journal of Toxicology Introduction Fulminant hepatitis is a rare condition but has a very poor prognosis in the absence of liver transplantation. It is important to identify the cause as soon as possible to start the etiological treatment, which may be drug poisoning, viral hepatitis, or alcoholic ... [1-3]. N-acetylcysteine (NAC), a glutathione precursor, was first used as a treatment for paracetamol overdose in 1979. Since then, it has been firmly established as an effective and safe treatment for paracetamol induced IHC prevention. NAC has also been shown to be effective outside paracetamol intoxication. It has been evaluated as an option for acute IHC other than paracetamol in adults and children. In a randomized clinical trial comparing NAC with placebo in adults with paracetamol-free IHC, NAC was associated with a marked improvement in survival without liver transplantation [4]. NAC has also been evaluated for non-hepatic clinical conditions, these...

Open Access Journal of Toxicology Abstract Microplastics are a pervasive environmental contaminant that have been found in many media including water sources, soils, and foodstuff. Due to the worldwide presence and persistence of microplastic debris, human exposure is inevitable. Human exposure occurs predominantly through ingestion, although dermal and inhalation exposures are probable. Microplastic single exposure studies in aquatic species and fish have shown various toxic effects including those on reproduction and survival. In addition to potential intrinsic toxicity, microplastics often have chemicals adsorbed to their surfaces. Studies report that these chemicals can have innate toxicity that is modulated by the composition of microplastics. Both the impacts of microplastics alone and co-exposures with adsorbed chemicals exhibit size dependent effects. Analysis of the current literature has revealed published studies predominantly investigate the toxicity of micropl...

  Open Access Journal of Toxicology Introduction Fish consider one of the healthiest food as it is low in fat and rich in protein and omega 3 Fayet-Moore [1] & Yipel [2]. The fish farming industry is rapidly expanding in Egypt, as well as in other countries, it has been associated with recurrent bacterial infectious diseases. Farmed Nile tilapia represents more than 58.45, while catfish production is about 3.08% of the total aquaculture harvest in Egypt Gafrd [3]. Antimicrobial medications are used extensively in aquacultures for prophylactic or therapeutic purposes during microbial infections which may result in environmental pollution, development of resistant bacteria and my induce toxicity to human and animals Aly [4] & Khalil [5]. The availability of adequate data on the pharmacokinetics of antimicrobial agents in farmed fish is very important in order to minimize the environmental impacts of the drugs used in aquaculture. Since the excess amount of dru...