Toxicity of Acacia Nilotica (Garad) to Nubian Goats – Juniper Publishers

JUNIPER PUBLISHERS-OPEN ACCESS JOURNAL OF TOXICOLOGY



Toxicity of Acacia Nilotica (Garad) to Nubian Goats

Authored by Medani AB

Abstract
Variable plants present in nature are used by simple rural and urban people, researchers and drug manufacturers for medicinal purposes. Garad is one of the most commonly used in Sudan for both treatment and prophylaxis of infections in the respiratory and urinogenital tracts and the skin. Water extracts from Acacia Nilotica bods were used in this very experiment to test for their toxicity to Nubian goats at two dose rates under proper experimental conditions. The clinical, pathological, hematological and biological changes in Nubian goats given daily oral doses of 1 and 5 g/kg body weight of Acacia Nilotica to two groups of goats. The goats of the control group were not dosed with Acacia Nilotica. Other than the dose co-related mortality rates, the clinical signs were observed to be salivation, staggered gait, intermittent loss of voice and low appetite. On histopathological testing, the main lesions were hepatic centrolobular necrosis and fatty changes associated with the significant changes in GGT and ALP were indicating hepatic dysfunction. Renal malfunction is indicated by hemorrhages in addition to the change in urea concentration. The congested, hemorrhagic, emphysematous, edematous and cyanotic lungs may contribute to the development of dyspnea. Acacia Nilotica poisoning may lead to an immuno suppression pointed out by the lymphocyte infiltration. On evaluation of the above results Acacia Nilotica was considered toxic to Nubian goats at the above-mentioned doses. Future work for Acacia Nilotica was forwarded and practical implications of the result were highlighted.

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