Toxicity of Cymbopogon proximus (Maharaib) Oil Extract to Newzealand Rabbits in Juniper Publishers

JUNIPER PUBLISHERS-OPEN ACCESS JOURNAL OF TOXICOLOGY



Toxicity of Cymbopogon proximus (Maharaib) Oil Extract to Newzealand Rabbits


Authored by Medani AB


Abstract

The clinical, pathological, hematological and biological changes in Newzealand rabbits’ groups given daily oral doses of 0.1, 0.25 and 0. 5 ml/kg body weight/day of Cpmbopogon proximus oil extract were investigated in experiment duration for 21 days. Other than the dose co-related mortality rates, the clinical signs were observed daily after dosing to be low appetite and nervous signs including restlessness and increased consciousness. Pulmonary excretion of the oil extract led to bloody spots on the lungs, lymphocyte infiltration, congestion and edema. Renal glomeruli manifested lymphocyte infiltration in addition to shrinkages and easinophilic material in the medulla, if considered with the corticomedullary generalized necrosis and the significant changes in urea, they may explain the renal dysfunction. Hepatic malfunction was manifested by significant changes in serum alkaline phosphatase and aspartate transferases accompanied by the congested fatty changed livers. The direct physical effect of the extracted oil was detected by the catarrhal inflammation of the intestines. There was no significant hematological change except for the slight changes in RBCs and MCVs in rabbits given the highest dose. Future work for Cymbopogon proximus oil extract was forwarded and practical implications of the result were highlighted.

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