Limited Usefulness of In Vitro Toxicity Data in Hazard Identification of Nanomaterials – Juniper Publishers


JUNIPER PUBLISHERS-OPEN ACCESS JOURNAL OF TOXICOLOGY



Limited Usefulness of In Vitro Toxicity Data in Hazard Identification of Nanomaterials

 

Authored by David Y Lai


Abstract
Short-term in vitro tests of toxicity can provide a rapid and relatively inexpensive way to assess the potential toxicity of large numbers of untested nano particles, and therefore, the number of in vitro studies of nano materials in the literature has sky rocketed in recent years. However, there are a number of inherent issues of in vitro test systems that result in false positives and false negatives, and recent studies have shown little correlation between in vitro and in vivo toxicity of nano materials. Some generic and specific issues of in vitro toxicity testing of nanomaterials are discussed.

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