JUNIPER PUBLISHERS-OPEN ACCESS JOURNAL OF TOXICOLOGY Toxicity of Cymbopogon proximus (Maharaib) Oil Extract to Newzealand Rabbits Authored by Medani AB Abstract The clinical, pathological, hematological and biological changes in Newzealand rabbits’ groups given daily oral doses of 0.1, 0.25 and 0. 5 ml/kg body weight/day of Cpmbopogon proximus oil extract were investigated in experiment duration for 21 days. Other than the dose co-related mortality rates, the clinical signs were observed daily after dosing to be low appetite and nervous signs including restlessness and increased consciousness. Pulmonary excretion of the oil extract led to bloody spots on the lungs, lymphocyte infiltration, congestion and edema. Renal glomeruli manifested lymphocyte infiltration in addition to shrinkages and easinophilic material in the medulla, if considered with the corticomedullary generalized necrosis and the significant changes in urea, they may explain the renal dysfuncti...
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